Wenjuan Xia, Yue Liu, Jiafeng Lu, Hoi-Hung Cheung, Qingxia Meng, and Boxian Huang

 

m6A and m5C are the most abundant methylation modifications in eukaryotic mRNA, playing crucial roles in regulating various biological processes and diseases. Neurons emerge at specific stages of brain development, which are essential for maintaining normal brain function. Research has shown a close relationship between neurodevelopmental disorders and RNA methylation modifications. In this issue, we summarize the regulation and functional roles of m6A and m5C in mammalian neurodevelopment, physiology, and disease. Brain development is a coordinated process that unfolds over time and space. As illustrated on the cover, neurodevelopment spans from childhood to old age, with RNA undergoing continuous methylation or demethylation to ensure the proper functioning of the nervous system at each stage of life.

 

This cover is designed by Yinxi Zhou and Jianfeng Jin from Hainan Medical University.