Impact Factor3.3
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Five-year Impact Factor3.4
|
{{lang == 'en_US' ? 'CSCD Impact Factor' : 'CSCD影响因子'}}0.4353
|
CiteScore 20225.0
|
Editor-in-ChiefDing, Jianping
Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids
Zhiwei Feng, Bingrui Zhou, Qizhi Shuai, Yunliang Wei, Ning Jin, Xiaoling Wang, Hong Zhao, Zhizhen Liu, Jun Xu, Jianbing Mu, and Jun Xie
Alcoholic liver disease (ALD) is a common liver disease and poses a significant health challenge. However, advancements in ALD research are impeded by the lack of suitable disease models. In this study, we differentiate human induced pluripotent stem cells (hiPSCs) into liver organoids composed of multiple liver cell components. Subsequently, these differentiated liver organoids are subject to ethanol treatment to induce ALD disease model. This model recapitulates some pathological features observed in clinical ALD, including hepatic fibrosis, fatty liver, and hepatocyte necrosis. In addition, this model can also be used for screening ALD therapeutic drugs and hold promise as ideal models for liver disease research. In the cover, the hiPSCs derived ALD liver from the liver organoids culture system drinks alcohol in front of two mirrors. The mirror in front (left) shows liver fibrosis, steatosis, inflammatory response, hepatocyte necrosis and other pathological manifestations during ALD. The mirror behind (right) shows the pathogenic mechanisms of mitochondrial damage, DNA destruction, oxidative stress, etc. during ALD.
This cover is designed by Yinxi Zhou and Jianfeng Jin from Hainan Medical University.
Impact Factor3.3
Five-year Impact Factor3.4
{{lang == 'en_US' ? 'CSCD Impact Factor' : 'CSCD影响因子'}}0.4353
CiteScore 20225.0
Editor-in-ChiefDing, Jianping
Ding, Jianping
Ding, Jianping
Cover Story
Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids
Zhiwei Feng, Bingrui Zhou, Qizhi Shuai, Yunliang Wei, Ning Jin, Xiaoling Wang, Hong Zhao, Zhizhen Liu, Jun Xu, Jianbing Mu, and Jun Xie
Alcoholic liver disease (ALD) is a common liver disease and poses a significant health challenge. However, advancements in ALD research are impeded by the lack of suitable disease models. In this study, we differentiate human induced pluripotent stem cells (hiPSCs) into liver organoids composed of multiple liver cell components. Subsequently, these differentiated liver organoids are subject to ethanol treatment to induce ALD disease model. This model recapitulates some pathological features observed in clinical ALD, including hepatic fibrosis, fatty liver, and hepatocyte necrosis. In addition, this model can also be used for screening ALD therapeutic drugs and hold promise as ideal models for liver disease research. In the cover, the hiPSCs derived ALD liver from the liver organoids culture system drinks alcohol in front of two mirrors. The mirror in front (left) shows liver fibrosis, steatosis, inflammatory response, hepatocyte necrosis and other pathological manifestations during ALD. The mirror behind (right) shows the pathogenic mechanisms of mitochondrial damage, DNA destruction, oxidative stress, etc. during ALD.
This cover is designed by Yinxi Zhou and Jianfeng Jin from Hainan Medical University.