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SCIENCE CHINA Materials, Volume 63 , Issue 12 : 2429-2434(2020) https://doi.org/10.1007/s40843-020-1513-8

Metal–organic framework-based nanocatalytic medicine for chemodynamic therapy

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  • ReceivedJul 9, 2020
  • AcceptedSep 8, 2020
  • PublishedOct 13, 2020

Abstract


Funded by

the National Natural Science Foundation of China(31971304,21601046)

the Natural Science Key Foundation of Hebei Province(B2017201226)

and Doctoral Candidate Innovation Funding Project of Hebei Province(CXZZBS2020022)


Acknowledgment

This work was supported by the National Natural Science Foundation of China (31971304 and 21601046), the Natural Science Key Foundation of Hebei Province (B2017201226), and the Doctoral Candidate Innovation Funding Project of Hebei Province (CXZZBS2020022).


Interest statement

The authors declare that they have no conflict of interest.


Contributions statement

Gao S and Han Y wrote the paper with support from Zhang J. All authors contributed to the general discussion.


Author information

Shutao Gao received his PhD degree in 2020 from Hebei University under the direction of Professor Jinchao Zhang. He is now a professor of Hebei Agricultural University. His main research interests are the preparation and applications of functional nanomaterials.


Yu Han received his BSc degree from Hebei University in 2015. He is now a PhD student of Hebei University. His research interests are nanomedicine and molecular diagnosis.


Jinchao Zhang received his PhD from Zhejiang University in 2001. He did postdoctoral research at Peking University from 2001 to 2003. Then, he worked as a senior visiting scholar at the City University of Hong Kong for three years. Currently, Dr. Zhang is a Professor at Hebei University. His research interests focus on the design and syntheses of nanomaterials for cancer diagnosis and therapy.


References

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  • Figure 1

    The mechanism for application of MOFs in chemodynamic therapy.

  • Figure 2

    Schematic of the synthesis of Hf-BPY-Fe and its anti-tumor mechanism. Reproduced with permission from ref. [17], Copyright 2020, American Chemical Society.

  • Figure 3

    Schematic of the synthesis of AMP and its anti-tumor mechanism. BTC stands for benzenetricarboxylic acid; AM represents ABTS@MIL-100; PAI stands for photoacoustic imaging. Reproduced with permission from ref. [19], Copyright 2019, John Wiley & Sons Inc.

  • Figure 4

    Schematic of the synthesis of CaO2@DOX@ZIF-67 and its anti-tumor mechanism. Reproduced with permission from ref. [23], Copyright 2019, John Wiley & Sons Inc.

  • Table 1   Examples of MOFs-based nanocatalytic medicines

    Nanocatalytic medicines/MOFs

    MOFs’ major components

    Fenton or Fenton-like catalyst

    Ref.

    rMOF/NH2-MIL-88B(Fe)

    Fe3+ and 2-aminoterephthalic acid

    Fe2+

    [13]

    MD@Lip/MOF-Fe2+

    Fe2+ and 2-aminoterephthalic acid

    Fe2+

    [14]

    Co-Fc@GOx/Co-Fc nMOF

    Co2+ and 1,1ʹ-ferrocenedicarboxylic acid

    Fe2+

    [15]

    Zr-Fc MOF

    Zr4+ and 1,1ʹ-ferrocenedicarboxylic acid

    Fe2+

    [16]

    Hf-BPY-Fe/Hf-nMOFs

    Hf4+ and 2,2ʹ-bipyridine-5,5ʹ-dicarboxylic acid

    Fe2+

    [17]

    MGH nanoamplifiers/MIL-100

    Fe3+ and 1,3,5-benzenetricarboxylic acid

    Fe3+

    [18]

    AMP NRs/MIL-101

    Fe3+ and 1,3,5-benzenetricarboxylic acid

    Fe3+

    [19]

    DMH NPs/MIL-100

    Fe3+ and 1,3,5-benzenetricarboxylic acid

    Fe3+

    [20]

    Cu-TBP nMOF

    Cu2+ and tetrakis(4-carboxyphenyl)porphyrin

    Cu2+

    [21]

    PCN-224(Cu)-GOD@MnO2/PCN-224

    Cu2+ and tetrakis(4-carboxyphenyl)porphyrin

    Cu+

    [22]

    CaO2@DOX@ZIF-67/ZIF-67

    Co2+ and 2-methylimidazole

    Co2+

    [23]

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