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SCIENCE CHINA Materials, Volume 63 , Issue 12 : 2397-2428(2020) https://doi.org/10.1007/s40843-020-1387-7

Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics

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  • ReceivedMar 3, 2020
  • AcceptedMay 7, 2020
  • PublishedAug 10, 2020

Abstract


Funding

the State Key Research Development Program of China(2019YFB2203503)

the National Natural Science Foundation of China(61875138,61435010,81972423,61961136001)

Science and Technology Innovation Commission of Shenzhen(KQTD2015032416270385,JCYJ20170811093453105,JCYJ20180307164612205,JCYJ20170307144246792,GJHZ20180928160209731,202050345)

Clinical research start-up plan of Southern Medical University(LC2016YM018)

Shenzhen Key Laboratory of Viral Oncology(ZDSYS201707311140430)

Grant of Sanming Medical Project(SM201702)

and Instrumental Analysis Center of Shenzhen University(Xili,Campus)


Acknowledgment

This work was supported by the State Key Research Development Program of China (2019YFB2203503), the National Natural Science Foundation of China (61875138, 61435010, 81972423 and 61961136001), Science and Technology Innovation Commission of Shenzhen (KQTD2015032416270385, JCYJ20170811093453105, JCYJ20180307164612205, JCYJ20170307144246792, GJHZ20180928160209731 and 202050345), the Clinical Research Start-up Plan of Southern Medical University (LC2016YM018), Shenzhen Key Laboratory of Viral Oncology (ZDSYS201707311140430), the Grant of Sanming Medical Project (SM201702), and the Instrumental Analysis Center of Shenzhen University (Xili Campus).


Interest statement

The authors declare that they have no conflict of interest.


Contributions statement

Zhang H and Hao Y provided the whole concept; Zhang H wrote the abstract, introduction and conclusion sections; Yang W and Lyu Q wrote the sections of 2D-nanomaterials for PDT, PTT, and SDT; Cao L summarized the references and Zhao J revised the manuscript. All authors contributed to the general discussion.


Author information

Wei Yang completed her BSc degree at Southern Medical University in 2012. Now she is pursuing her MSc degree in Southern Medical University, and her research interests focus on the biomedical applications of nanomaterials and development of functional nanostructures for cancer sonodynamic therapy.


Qinghua Lyu completed his BSc degree at China Pharmaceutical University and then obtained his PhD degree in the National University Singapore in 2019. He continued his academic research as a post-doctoral fellow in the School of Ophthalmology & Optometry Affiliated to Shenzhen University, and his research interests include medicinal chemistry, fabrication and modification of biomaterials and natural polymers for biomedical applications.


Yi Hao received his BSc degree at Xinjiang Medical University in 2004. He obtained his MSc degree at Xinjiang Medical University in 2009. Currently, he is a doctor in Shenzhen Hospital affiliated to Southern Medical University and his main research interests concern the ultrasonic diagnosis of tumor, modification and application of ultrasound microbubbles and nanomaterials in cancer therapy.


Han Zhang received his BSc degree from Wuhan University (2006) and PhD degree from Nanyang Technological University (2010). In 2012, he joined the College of Optoelectronic Engineering (Collaborative Innovation Centre for Optoelectronic Science Technology), Shenzhen University as a full professor. His current research is on the ultrafast, nonlinear photonics, and biomedicine of 2D materials.


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  • Figure 1

    Structural representation of 2D layered materials. (a) Graphene, (b) GDY, (c) black phosphorus, (d) TMDs, (e) two stable allotropes of antimonene, (f) hexagonal boron nitride. (a, c, d, f) Reprinted with permission from Ref. [47], Copyright 2019, the Royal Society of Chemistry; (b) Reprinted with permission from Ref. [48], Copyright 2018, American Chemical Society; (e) Reprinted with permission from Ref. [49], Copyright 2016, the Royal Society of Chemistry.

  • Figure 2

    Illustrations of preparing GQDs/DOX/BCPV/siRNA nanoplatforms for pancreatic cancer synergistic therapy. Reprinted with permission from Ref. [192], Copyright 2018, American Chemical Society.

  • Figure 3

    Illustration of GDY/DOX combining PTT and chemotherapy treatment. Reprinted with permission from Ref. [95], Copyright 2018, American Chemical Society.

  • Figure 4

    In vivo ultrasound/PA (a) and fluorescence (b) images of MCF-7 breast tumor-bearing mice after injection of AM-PEG NSs and Cy5.5-labeled AM-PEG NSs, respectively. Reprinted with permission from Ref. [129], Copyright 2018, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  • Figure 5

    Illustration of preparing MoS2-SS-HA-CPT nanocomposites for synergetic chemo-photothermal cancer therapy. Reprinted with permission from Ref. [244], Copyright 2019, BioMed Central Ltd. unless otherwise stated. Part of Springer Nature.

  • Figure 6

    Schematic illustration of preparing Ti3C2@mMSNs-RGD for synergistic chemo-PTT against HCC with potential PA-imaging guidance and monitoring. Reprinted with permission from Ref. [155], Copyright 2018, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  • Figure 7

    (a, c) Schematic illustrations of preparing Pd@OH-BNNS/DOX for combinational chemotherapy and PTT; (b) TEM images of OH-BNNS (1 and 2) and Pd@OH-BNNS (3 and 4). Reprinted with permission from Ref. [271], Copyright 2019, Elsevier B.V.

  • Figure 8

    Schematic illustrations of preparing PC@GCpD (Gd)nanohybrids for MRI/fluorescence bimodal imaging-guided photo-immunotherapy. Reprinted with permission from Ref. [303], Copyright 2019, Elsevier B.V.

  • Figure 9

    (a) Schematic for the preparation of BP-based dual-triggered oxygen self-supply nanoplatforms (Cy5-dHeme-BPNS-FA) for enhanced PDT and illustration of their intracellular actions in the body. Reprinted with permission from Ref. [310], Copyright 2018, Elsevier Ltd. (b) Schematic illustration of synthesis of R-MnO2-FBP and the mechanism of self-supply oxygen for enhanced PDT. Reprinted with permission from Ref. [311], Copyright 2018, Elsevier Ltd.

  • Figure 10

    Schematic illustration of the preparation of AM-based NPs (CmNP) and for multimodality imaging-guided PDT/PTT. Reprinted with permission from Ref. [130], Copyright 2019, the Royal Society of Chemistry.

  • Figure 11

    (a) Schematic for synthesis of MoS2@ss-SiO2-Ce6/HA nanocomposites and its mechanisms for multimodal imaging-guided PTT and PDT. Reprinted with permission from Ref. [315], Copyright 2019, American Chemical Society.

  • Figure 12

    Schematic of preparing Au NPL@TiO2 nanostructures for PTT/SDT against HeLa cells. Reprinted with permission from Ref. [346], Copyright 2019, the Royal Society of Chemistry.

  • Figure 13

    (a, b) Preparation of Au@BP nanohybrids for SDT-based cancer treatment under ultrasound irradiation. (c) The ROS production percentages of Au@BP nanohybrids under 660 nm NIR or ultrasound irradiation with/without pork skin screening. Reprinted with permission from Ref. [350], Copyright 2018, the Royal Society of Chemistry.

  • Table 1   Summary of 2D nanomaterials for PTT applications

    Therapeutic platform

    2D nanomaterials

    In vitro

    In vivo

    PTCefficiency (%)

    Therapy strategy

    Ref.

    rGO/(PLL/PASP)n@DOX

    rGO nanosheets

    Hela cell line

    24.30

    PTT, chemotherapy

    [188]

    GO(PEG-PpIX)

    GO nanosheets

    4T1 cell/Hela cell line

    4T1 tumor-bearing mice

    PTT, PDT, chemotherapy

    [189]

    PEG-rGO-FA-IDOi

    rGO nanosheets

    CT26 cell line

    CT26 tumor-bearing mice

    PTT/immunotherapy

    [69]

    DOX-MMSN/GQDs

    GQDs

    4T1 cell line

    PTT/chemotherapy/magnetichyperthermia therapy

    [191]

    GQD/DOX/BCPV/siRNA

    GQDs

    MiaPaCa-2 cell line

    PTT/chemotherapy/gene therapy

    [192]

    Au/DOX@GQDs-FA

    GQDs

    Hela/A549 cell line

    Hela tumor-bearing mice

    51.31

    PA/CT imaging-guidedPTT/chemotherapy

    [195]

    GDY-PEG

    GDY nanosheets

    4T1 cell line

    4T1 tumor-bearing mice

    42.00

    PA imaging-guided PTT

    [94]

    GDY/DOX

    GDY nanosheets

    MDA-MB-231/MCF-7/ A549 cell line

    MDA-MB-231tumor-bearing mice

    42.00

    PTT, chemotherapy

    [95]

    BP-DEX/PEI-FA/Cy7

    BP nanosheets

    4T1 cell line

    4T1 tumor-bearing mice

    41.00

    NIRF/PA imaging-guided PTT

    [219]

    BP@PEG/Ce6

    BP nanosheets

    Hela cell line

    Hela tumor-bearing mice

    43.60

    PTT/PDT

    [220]

    BP/DTX@PLGA

    BPQDs

    4T1-LG12 cell line

    4T1-LG12 lung metastatic tumors

    PTT/chemotherapy

    [231]

    BPQDS-PEG-FA/DOX

    BPQDs

    Hela cell line

    Hela tumor-bearing mice

    PTT/chemotherapy

    [232]

    MoS2-SS-HA-CPT

    MoS2 nanosheets

    A549 cell line

    A549 lung cancer cell-bearing mice

    28.80

    PTT/chemotherapy

    [244]

    PEGylated-MoS2/Cu1.8S

    MoS2 nanosheets

    A549 cell line

    A549 lung cancer cell-bearing mice

    32.50

    PTT/chemotherapy

    [245]

    NIR-CD/MoS2

    MoS2 nanosheets

    Hela cell line

    4T1 tumor-bearing mice

    78.20

    PTT/chemotherapy

    [246]

    MoS2@PANI

    MoS2 QDs

    4T1 cell line

    4T1 tumor-bearing mice

    31.60

    PTT/RTa

    [248]

    DOX-POV-MoS2-Tf

    MoS2 nanodots

    HepG2 cell line

    PTT/chemotherapy

    [249]

    WS2-Ga3+-PEG

    WS2 nanosheets

    HepG2 cell line

    HepG2 tumor-bearing mice

    PTT

    [250]

    WS2-IO/S@MO-PEG

    WS2 nanoflakes

    4T1 cell line

    4T1 tumor-bearing mice

    PTT/RT

    [251]

    DOX@Fe(III)@WS2-PVP

    WS2 nanosheets

    HT29 cell line

    HT29 tumor-bearing mice

    39.10

    PTT/chemotherapy

    [252]

    Ti3C2-SP

    Ti3C2 nanosheets

    4T1 cell line

    4T1 tumor-bearing mice

    PTT/chemotherapy

    [154]

    DOX/Ti3C2@mMSNs-RGD

    Ti3C2 nanosheets

    HCC cell line

    HCC-tumor-bearing mice

    23.20

    PTT/chemotherapy

    [155]

    Ta4C3-SP

    Ta4C3 nanosheets

    4T1 cell line

    4T1 tumor-bearing mice

    44.70

    PTT

    [266]

    Ti2C-PEG

    Ti2C nanosheets

    A375/MCF-7 cell line

    87.10

    PTT

    [152]

    MXene QDs

    MXene QDs

    Hela cell line

    Hela tumor-bearing mice

    52.20

    PTT

    [267]

    PEG-coated AMQDs

    AMQDs

    MCF-7/Hela cell line

    MCF-7 tumor-bearing mice

    45.50

    PTT

    [120]

    AM-PEG/DOX NSs

    AM nanosheets

    MCF-7 cells

    MCF-7 tumor-bearing mice

    41.80

    PTT/chemotherapy

    [129]

    hBNI/d-HA-Dox

    hBN nanosheets

    MDAMB-231 cell line

    PTT/chemotherapy

    [270]

    Pd@OH-BNNS

    BN nanosheets

    MCF-7 cell line

    S180 tumor-bearing mice

    PTT/chemotherapy

    [271]

    ICG-DOX/Gd-LDH

    LDH

    Hela cell line

    Hela tumor-bearing mice

    PTT/PDT

    [274]

    5-FU/Cu-LDH

    LDH

    HCT-116 colon cancer cells

    HCT-116 colon tumor-bearingnude mice

    53.1

    PTT/chemotherapy

    [275]

    RT: radiation therapy.

  • Table 2   Summary of various 2D nanomaterials for PDT and SDT applications

    Therapeutic platform

    2D nanomaterials

    In vitro

    In vivo

    Therapy strategy

    Ref.

    NGO-mPEG/ZnPc

    NGO

    MCF-7 breast cancer cell line

    PDT

    [295]

    NGP-AIE

    NGO

    UMUC3 cell line

    UMUC3 tumor xenograft model

    PDT

    [299]

    chit-rGO-IR820-DOX

    rGO

    CT26 cell line

    PDT, PTT, chemotherapy

    [300]

    UCNs-GOQDs-FA/TPP

    GOQDs

    HeLa cells

    HeLa tumor model

    PDT

    [302]

    PC@GCpD(Gd)

    GQDs

    EMT6 cell line

    EMT6 tumor-bearing mice

    PDT, PTT, chemotherapy

    [303]

    BP nanosheets

    BP nanosheets

    MDA-MB-231 cell line

    Xenograft tumor model

    PDT

    [114]

    PEGylated BPQDs

    BPQDs

    HeLa cell or L02 cell line

    S180 tumor bearing mice model

    PDT

    [351]

    PEGylated BPQDs

    BPQDs

    Hep G2 cells

    4T1 tumor-bearing Balb/c mice

    PDT, PTT

    [228]

    R-MnO2-FBP

    BP nanosheets

    HeLa cells

    HeLa tumor model

    PDT

    [311]

    Cy5-dHeme-BPNS-FA

    BP nanosheets

    HeLa cells

    HeLa tumor model

    PDT

    [310]

    MnO2-UCNPs-FA/ZnPc

    MoS2 nanosheet

    MDA-MB-231/ HCC38/ MCF-7 cells

    HCC38 orthotopic triple-negative breast tumor model

    PTT, PDT

    [313]

    PEG-MnO2-Au-Ce6

    MoS2 nanosheet

    4T1 cells

    4T1 tumor-bearing mice

    PTT, PDT

    [314]

    MnO2@ss-SiO2-Ce6/HA

    MoS2 nanodots

    4T1 cells

    4T1-tumor-bearing mice

    PTT, PDT

    [315]

    HA-WS2@PANI/Ce6

    WS2 nanodots

    4T1 cells

    4T1 tumor-bearing nude mice

    PTT, PDT, RT

    [316]

    Ti3C2-DOX

    Ti3C2 nanosheets

    HCT-116 and A2780 cell line

    Tumor bearing mice

    PDT, PTT, chemotherapy

    [317]

    CmNP

    AM nanosheets

    4T1 cells

    4T1-xenografted mice

    PTT, PDT

    [130]

    LDH-ZnPcS8

    LDH

    HepG2 cell line

    H22 tumor-bearing mice

    PDT

    [319]

    FeMn-LDH/MB

    LDH

    HeLa cells

    HeLa-tumor-bearing nude mice

    PDT/PTT

    [273]

    Ce6/CoMn-LDH

    LDH

    HeLa cells

    HeLa-tumor-bearing nude mice

    PDT/CDT

    [320]

    nrGO@MSN-ION-PEG-RB

    rGO

    SKBr3 cells

    SKBr3 tumor bearing nude mice

    SDT

    [341]

    MnOx/TiO2-GR-PVP

    rGO

    4T1 cells

    4T1-tumor-bearing mice

    SDT

    [342]

    HAu-TiO2 NCs

    Au

    SCC7 cells

    SCC7 tumor-bearing mice

    SDT

    [345]

    Au NPL@TiO2

    Au nanoplate

    HeLa cells

    HeLa-tumor-bearing nude mice

    SDT

    [346]

    Au@BP

    BP nanosheets

    4T1 cells

    4T1-tumor-bearing mice

    SDT

    [350]

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