A novel GSH responsive poly(alpha-lipoic acid) nanocarrier bonding with the honokiol-DMXAA conjugate for combination therapy

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  • ReceivedJun 22, 2019
  • AcceptedSep 10, 2019
  • PublishedOct 21, 2019



Ministry of Science and Technology of China(2018ZX09711003-012)

the National Natural Science Foundation of China(51873206,51673189,51829302,51503202,51833010,51520105004)

and the Program of Scientific Development of Jilin Province(20190103033JH)


This work was supported by the Ministry of Science and Technology of China (2018ZX09711003-012), the National Natural Science Foundation of China (51873206, 51673189, 51829302, 51503202, 51833010 and 51520105004), and the Program of Scientific Development of Jilin Province (20190103033JH).

Interest statement

The authors declare that they have no conflict of interest.

Contributions statement

Tang Z and Chen X put forward research ideas. Liu Z designed and synthesized the samples, Si X and Wu J performed some chemical synthesis experiments, Shen N and Zhang D performed the animal experiments; Liu Z wrote the paper with support from Tang Z and Chen X. All authors contributed to the general discussion.

Author information

Zhilin Liu is a PhD candidate at the University of Science and Technology of China. His current research focuses on the tumor-microenvironment responsive nanomedicine of drug delivery system.

Zhaohui Tang is a professor in Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. His research interests are focused on polymeric carriers for tumor treatment and combinational therapy. He has published more than 100 papers in SCI journals, such as Progress in Polymer Science, Advanced Materials, Advanced Science, Biomaterials, Small and Chemical Science.

Xuesi Chen is a professor in Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. His research interests are focused on polymers chemistry on biomedical polymers, biodegradable polymers for drug/gene controlled release, bone repair parts and tissue engineering scaffolds. He published more than 600 papers in SCI journals, such as Progress in Polymer Science, Advanced Materials, Journal of the American Chemical Society and Advanced Functional Materials. He was authorized more than 200 Chinese invention patents.

Supplementary data

Supplementary information

Supporting data are available in the online version of the paper.


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