SCIENCE CHINA Life Sciences, Volume 62 , Issue 11 : 1459-1471(2019) https://doi.org/10.1007/s11427-019-9823-1

Dynamic modifications of biomacromolecules: mechanism and chemical interventions

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  • ReceivedJul 28, 2019
  • AcceptedAug 20, 2019
  • PublishedSep 18, 2019




Table S1 List of research projects that have been funded by the Major Research Project at NSFC

The supporting information is available online at http://life.scichina.com and https://link.springer.com. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.


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  • Figure 1

    The dynamic chemical modifications of biomacromolecules support the complexity of life beyond “central dogma”.

  • Figure 2

    The organization of the NSFC Major Research Plan on studying dynamic modifications of biomacromolecules.

  • Figure 3

    The computer-aided, proximal decaging (CAGE-prox) technique as a universal protein activation strategy for time-resolved study of protein functions, interactions and PTMs in living systems. A, CAGE-prox concept and workflow. B, Representative proteins of various types of enzymes activated using GAGE-prox.

  • Figure 4

    Cholesterol can covalently modify the D95 of human SMO or D99 of mouse SMO. This cholesterylation is inhibited by PTCH1 and enhanced by Shh that is also linked to cholesterol. The homozygous D99N/D99N knock-in mouse showed severe developmental defects and is embryonic lethal.

  • Figure 5

    Chemical protein synthesis of post-translationally modified proteins/probes and their representative applications for the studies of the dynamic regulation mechanisms of ubiquitin chains and ubiquitinated nucleosomes.

  • Figure 6

    Site-selective labeling of protein by the visible light initiated bioorthogonal photo-click cycloaddition.


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