SCIENCE CHINA Life Sciences, Volume 63 , Issue 1 : 152-156(2020) https://doi.org/10.1007/s11427-019-1578-9

Smart calcium peroxide with self-sufficience for biomedicine

More info
  • ReceivedOct 8, 2019
  • AcceptedOct 30, 2019
  • PublishedNov 28, 2019


There is no abstract available for this article.


the National Natural Science Foundation of China(31971304,21601046)

the Natural Science Key Foundation of Hebei Province(B2017201226)


This work was supported by the National Natural Science Foundation of China (31971304, 21977024 and 21601046) and Natural Science Key Foundation of Hebei Province (B2017201226).

Interest statement

The author(s) declare that they have no conflict of interest.


[1] Chandra P.K., Ross C.L., Smith L.C., Jeong S.S., Kim J., Yoo J.J., Harrison B.S.. Peroxide-based oxygen generating topical wound dressing for enhancing healing of dermal wounds. Wound Rep Reg, 2015, 23830-841 CrossRef PubMed Google Scholar

[2] Chang C.W., Wang M.J.. Preparation of microfibrillated cellulose composites for sustained release of H2O2 or O2 for biomedical applications. ACS Sustain Chem Eng, 2013, 11129-1134 CrossRef Google Scholar

[3] Coronel M.M., Liang J.P., Li Y., Stabler C.L.. Oxygen generating biomaterial improves the function and efficacy of beta cells within a macroencapsulation device. Biomaterials, 2019, 2101-11 CrossRef PubMed Google Scholar

[4] Fan W., Qi Y., Wang R., Xu C., Zhao N., Xu F.J.. Calcium carbonate-methylene blue nanohybrids for photodynamic therapy and ultrasound imaging. Sci China Life Sci, 2018, 61483-491 CrossRef PubMed Google Scholar

[5] Fu X.. Regenerative medicine in China: New advances and hopes. Sci China Life Sci, 2018, 611135-1136 CrossRef PubMed Google Scholar

[6] Gao S., Lu X., Zhu P., Lin H., Yu L., Yao H., Wei C., Chen Y., Shi J.. Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy. J Mater Chem B, 2019, 73599-3609 CrossRef Google Scholar

[7] Hameed S., Bhattarai P., Dai Z.. Nanotherapeutic approaches targeting angiogenesis and immune dysfunction in tumor microenvironment. Sci China Life Sci, 2018, 61380-391 CrossRef PubMed Google Scholar

[8] Hu L., Wang P., Zhao M., Liu L., Zhou L., Li B., Albaqami F.H., El-Toni A.M., Li X., Xie Y., et al. Near-infrared rechargeable “optical battery” implant for irradiation-free photodynamic therapy. Biomaterials, 2018, 163154-162 CrossRef PubMed Google Scholar

[9] Huang C.C., Chia W.T., Chung M.F., Lin K.J., Hsiao C.W., Jin C., Lim W.H., Chen C.C., Sung H.W.. An implantable depot that can generate oxygen in situ for overcoming hypoxia-induced resistance to anticancer drugs in chemotherapy. J Am Chem Soc, 2016, 1385222-5225 CrossRef PubMed Google Scholar

[10] Ji C., Lu Z., Xu Y., Shen B., Yu S., Shi D.. Self-production of oxygen system CaO2/MnO2@PDA-MB for the photodynamic therapy research and switch-control tumor cell imaging. J Biomed Mater Res, 2018, 1062544-2552 CrossRef PubMed Google Scholar

[11] Kang J.I., Park K.M., Park K.D.. Oxygen-generating alginate hydrogels as a bioactive acellular matrix for facilitating wound healing. J Ind Eng Chem, 2019, 69397-404 CrossRef Google Scholar

[12] Liu L.H., Zhang Y.H., Qiu W.X., Zhang L., Gao F., Li B., Xu L., Fan J.X., Li Z.H., Zhang X.Z.. Dual-stage light amplified photodynamic therapy against hypoxic tumor based on an O2 self-sufficient nanoplatform. Small, 2017, 131701621 CrossRef PubMed Google Scholar

[13] Pan X., Wang H., Wang S., Sun X., Wang L., Wang W., Shen H., Liu H.. Sonodynamic therapy (SDT): A novel strategy for cancer nanotheranostics. Sci China Life Sci, 2018, 61415-426 CrossRef PubMed Google Scholar

[14] Park S., Park K.M.. Hyperbaric oxygen-generating hydrogels. Biomaterials, 2018, 182234-244 CrossRef PubMed Google Scholar

[15] Pedraza E., Coronel M.M., Fraker C.A., Ricordi C., Stabler C.L.. Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials. Proc Natl Acad Sci USA, 2012, 1094245-4250 CrossRef PubMed Google Scholar

[16] Shen S., Mamat M., Zhang S., Cao J., Hood Z.D., Figueroa-Cosme L., Xia Y.. Synthesis of CaO2 nanocrystals and their spherical aggregates with uniform sizes for use as a biodegradable bacteriostatic agent. Small, 2019, 151902118 CrossRef PubMed Google Scholar

[17] Sheng Y., Nesbitt H., Callan B., Taylor M.A., Love M., McHale A.P., Callan J.F.. Oxygen generating nanoparticles for improved photodynamic therapy of hypoxic tumours. J Control Release, 2017, 264333-340 CrossRef PubMed Google Scholar

[18] Tang Z., Liu Y., He M., Bu W.. Chemodynamic therapy: Tumour microenvironment-mediated fenton and Fenton-like reactions. Angew Chem Int Ed, 2019, 58946-956 CrossRef PubMed Google Scholar

[19] Touri M., Moztarzadeh F., Osman N.A.A., Dehghan M.M., Mozafari M.. 3D-printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival. Mater Sci Eng C, 2018, 84236-242 CrossRef PubMed Google Scholar

[20] Touri M., Moztarzadeh F., Osman N.A.A., Dehghan M.M., Mozafari M.. Optimisation and biological activities of bioceramic robocast scaffolds provided with an oxygen-releasing coating for bone tissue engineering applications. Ceram Int, 2019, 45805-816 CrossRef Google Scholar

[21] Yan Z., Bing W., Ding C., Dong K., Ren J., Qu X.. A H2O2-free depot for treating bacterial infection: Localized cascade reactions to eradicate biofilms in vivo. Nanoscale, 2018, 1017656-17662 CrossRef PubMed Google Scholar

[22] Zhang C., Bu W., Ni D., Zhang S., Li Q., Yao Z., Zhang J., Yao H., Wang Z., Shi J.. Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized Fenton reaction. Angew Chem Int Ed, 2016, 552101-2106 CrossRef PubMed Google Scholar

[23] Zhang H., Liu X.L., Zhang Y.F., Gao F., Li G.L., He Y., Peng M.L., Fan H.M.. Magnetic nanoparticles based cancer therapy: Current status and applications. Sci China Life Sci, 2018, 61400-414 CrossRef PubMed Google Scholar

[24] Zhang M., Song R., Liu Y., Yi Z., Meng X., Zhang J., Tang Z., Yao Z., Liu Y., Liu X., et al. Calcium-overload-mediated tumor therapy by calcium peroxide nanoparticles. Chem, 2019, 52171-2182 CrossRef Google Scholar

[25] Zhang T., Han Z., Zhang W., Wang J., Xu L.. Cyanoacrylate-encapsulated calcium peroxide achieved oxygen-sustained release and promoted wound healing. Int J Polym Mater Polym Biomater, 2019, doi: 10.1080/00914037.2019.1600518 CrossRef Google Scholar


Contact and support