SCIENCE CHINA Life Sciences, Volume 59 , Issue 3 : 281-291(2016) https://doi.org/10.1007/s11427-015-4973-6

Ghrelin O-acyltransferase (GOAT) and energy metabolism

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  • ReceivedAug 17, 2015
  • AcceptedOct 9, 2015
  • PublishedJan 4, 2016


Funded by

National Natural Science Foundation of China(81330010,81390354)

American Diabetes Association grant(1-13-BS-225)


Acknowledgements This work was supported by the National Natural Science Foundation of China (81330010, 81390354) and American Diabetes Association grant (1-13-BS-225).

Interest statement

Compliance and ethics The author(s) declare that they have no conflict of interest.


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  • Figure 1

    Roles of GOAT/acyl-ghrelin system in energy metabolism. Octanoylation of ghrelin (sequence as: GSSFLSPEHQKAQQRKESKKPPAKLQPR) by ghrelin O-acyltransferase (GOAT) on its third amino acid (serine-3) is necessary for the hormone’s biological functions, Octanoylated ghrelin regulates food intake by inducing hyperphagia and increasing gastrointestinal motility, modulates glucose metabolism by altering insulin secretion and sensitivity, as well as stimulates adiposity by increasing lipid storage and/or decreasing lipid expenditure.


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