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SCIENTIA SINICA Chimica, Volume 48 , Issue 11 : 1347-1364(2018) https://doi.org/10.1360/N032018-00100

Recent progress of novel anti-influenza entry inhibitors

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  • ReceivedApr 23, 2018
  • AcceptedJul 23, 2018
  • PublishedOct 16, 2018

Abstract


Funded by

国家自然科学基金(91753202,81573269,21572015,21702007)


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  • Figure 1

    The process by which influenza virus entries into the cell (color online).

  • Figure 2

    Structure of HA protein. (a) HA trimer; (b) HA monomer; (c) pH induces HA conformation change [21] (color online).

  • Figure 3

    Structures of pentacyclic triterpene derivatives 117 and their multivalent conjugates 1822 (color online).

  • Figure 4

    Structures of polyphenols 2337.

  • Figure 5

    Structures of natural products 3844 and teicoplanin derivatives 4546.

  • Figure 6

    Amino acid sequences of peptides 5559, 66 and 74.

  • Figure 7

    Structures of compounds 75107.

  • Table 1   Antiviral activities of FluPeps on A/WSN/33 (H1N1) virus

    多肽

    序列

    IC50 (μM)

    48(FP1)

    WLVFFVIFYFFR

    0.094

    49(FP2)

    WLVFFVIAYFAR

    0.00087

    50(FP3)

    WLVFFVIFYFFRRRKK

    0.00003

    51(FP4)

    RRKKWLVFFVIFYFFR

    0.00004

    52(FP7)

    RRKKIFYFFR

    0.155

    53(FP8)

    WLVFFVRRKK

    0.64

    54(FP9)

    FFVIFYRRKK

    1.48

  • Table 2   Anti-influenza activities of peptides derived from influenza type A viruses

    多肽

    氨基酸序列

    流感亚型

    IC50 (μg/mL)

    H1N1

    H3N2

    60 (HA-FP-0)

    GLFGAIAGFIENGWEGMIDG

    H3

    NA

    NA

    61 (HA-FP-1)

    GLFGAIAGFIKNGWKGMIKG

    H3

    9.61±1.15

    5.90±0.62

    62 (HA-FP-2)

    GLFGAIAGFIKGGWQGMVKG

    H5

    11.96±0.80

    15.64±0.11

    63 (HA-FP-2-1)

    GLFGAIAGFIKKGWKGMVKG

    H5

    11.19±0.63

    28.17±1.96

    64 (HA-FP-3)

    GLFGAIAGFIKGGWPGLVKG

    H9

    15.17±3.69

    34.91±4.21

    65 (HA-FP-3-1)

    GLFGAIAGFIKKGWPGLVKG

    H9

    10.37±0.05

    27.57±0.43

qqqq

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