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SCIENCE CHINA Chemistry, Volume 63 , Issue 9 : 1281-1288(2020) https://doi.org/10.1007/s11426-020-9779-1

Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability

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  • ReceivedMay 13, 2020
  • AcceptedMay 21, 2020
  • PublishedJul 14, 2020

Abstract


Funding

the National Natural Science Foundation of China(21634003,51673043)

Ministry of Science and Technology of China(2016YFA0203302)

STCSM(17QA1400400)

SHMEC(2017-01-07-00-07-E00062)

Yanchang Petroleum Group.


Acknowledgment

This work was supported by the National Natural Science Foundation of China (21634003, 51673043), Ministry of Science and Technology of China (2016YFA0203302), Science and Technology Commission of Shanghai Municipality (17QA1400400), Shanghai Municipal Education Commission (2017-01-07-00-07-E00062) and Yanchang Petroleum Group.


Interest statement

The authors declare no conflict of interest.


Supplementary data

Supporting Information

The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.


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  • Figure 1

    The structure of fiber-shaped all-in-one OECTs. (a) Schematic illustration of a fiber-shaped all-in-one OECT. (b) Representative SEM image of a fiber-shaped all-in-one OECT. (c) SEM image of the boundary between semi-conductor PEDOT:PSS and insulator parylene on Au-coated nylon fiber. (d) Cross-sectional SEM image of PEDOT:PSS coated nylon fiber. (e, f) SEM images of CNT fiber gate electrode modified with Pt NPs at low and high magnifications, respectively (color online).

  • Figure 2

    High sensitivity of the fiber-shaped OECTs. (a) The circuit diagram of the OECTs (S for source, D for drain and G for gate). (b, c) Transfer and output curves of the OECTs using 0.01 M PBS as the electrolyte, respectively. (d, e) Drain current and gate current of the OECT in response to the same H2O2 addition at the same time (VD fixed at −0.6 V and VG fixed at 0.4 V), respectively. (f) Current versus time with the addition of H2O2 as potential of 0.4 Vvs. Ag/AgCl reference electrode. (g) Normalized electrochemical areas of different fiber electrodes. (h) Drain current responses of a fiber-shaped OECT to the addition of H2O2 with different concentrations. (i) Corresponding current change in function of H2O2 concentration at (h) (inset, linear range of low concentration) (color online).

  • Figure 3

    High stability and biocompatibility of the fiber-shaped OECTs. (a) Normalized drain current in response to the cycling pulse of potential. (b) Effective Young’s modulus tested by nanoindentation among biological tissues, CNT fiber, nylon fiber, polyimide film (PI), Au wire and silicon wafer. (c, d) Normalized transconductance of channel and impedance of gate electrode under 2,000 bending cycles, respectively. (e, f) Normalized transconductance of channel and impedance of the gate electrode during 7 d at 37 °C in 0.01 M PBS, respectively. (g) Representative fluorescence images of coronal brain slices with implanted fiber-shaped OECTs for 7 d and the control group without implants. Immunofluorescent staining for 4′,6-diamidino-2-phenylindole (DAPI, blue), neurons (NeuN, green), glial fibrillary acidic protein (GFAP, red) and the merged signals are provided for clarification. The white dotted line indicates the position of fiber-shaped device (color online).

  • Figure 4

    Multi-functionalization and in vivo detection of the fiber-shaped OECTs. (a) Schematic illustration for the gate electrode of fiber-shaped dopamine-OECT and the mechanism of DA detection. (b) Drain current responses of the dopamine-OECT (inset, the representative linear range). (c) The anti-interference characterization of the dopamine-OECT. (d) Schematic illustration for the gate electrode of fiber-shaped glutamate-OECT and the mechanism of glutamate detection. (e) Drain current responses of the glutamate-OECT (inset, the representative linear range). (f) The anti-interference characterization of the glutamate-OECT. (g) Schematic illustration for the gate electrode of fiber-shaped glucose-OECT and the mechanism of glucose detection. (h) Drain current responses of the glucose-OECT (inset, the representative linear range). (i) The anti-interference characterization of the glucose-OECT. (j–l) In vivo detection of DA using the dopamine-OECT for 7 d in the same mouse brain (color online).

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