It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy, lesion-targeted precision and easy accessibility. Herein, Prof. Zhe Liu et al. fabricated the engineered BaTiO3-based nanocomposites with photodynamic and pyroelectric performances and applied them to the photo/pyroelectric dynamic treatments. The continuing ROS production derived from intracellular oxygen (O2) and water (H2O) contributed together to the superb tumor cell apoptosis and significant tumor growth inhibition under an external NIR irradiation. This study has validated a new concept of drug-device-field integration (DDFI) by depositing these nanocomposites at tumors, exerting NIR exposure by a medical laser device, facilitating reactive oxygen species (ROS) release as killers and ultimately achieving tumor cell apoptosis with high therapeutic efficiency and expectable translational perspectives. The cover quotes a Greek myth of Trojan Horses to depict this research in order to elucidate this philosophy to a wide readership in the trans-disciplinary scientific community (see the article on pages 3050–3062).

It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy, lesion-targeted precision and easy accessibility. Herein, Prof. Zhe Liu et al. fabricated the engineered BaTiO3-based nanocomposites with photodynamic and pyroelectric performances and applied them to the photo/pyroelectric dynamic treatments. The continuing ROS production derived from intracellular oxygen (O2) and water (H2O) contributed together to the superb tumor cell apoptosis and significant tumor growth inhibition under an external NIR irradiation. This study has validated a new concept of drug-device-field integration (DDFI) by depositing these nanocomposites at tumors, exerting NIR exposure by a medical laser device, facilitating reactive oxygen species (ROS) release as killers and ultimately achieving tumor cell apoptosis with high therapeutic efficiency and expectable translational perspectives. The cover quotes a Greek myth of Trojan Horses to depict this research in order to elucidate this philosophy to a wide readership in the trans-disciplinary scientific community (see the article on pages 3050–3062).