Impact Factor3.7
|
Five-year Impact Factor3.9
|
{{lang == 'en_US' ? 'CSCD Impact Factor' : 'CSCD影响因子'}}0.4353
|
CiteScore 20224.4
|
Editor-in-ChiefDing, Jianping
8-Oxoguanine DNA glycosylase protects cells from senescence via the p53-p21 pathway
Shenglan Gao, Lujun Chen, Ziying Lin, Zhiliang Xu, Yahong Wang, Huayu Ling, Zijun Wu, Yu Yin4, Weimin Yao, Keng Wu, and Gang Liu
p53, the tumor suppressor, plays an important role in senescence via its downstream target p21. The DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) involves in early embryonic development, and in a variety of diseases such as lung fibrosis, diabetes, and neurodegenerative diseases. This article investigates the important protective role of OGG1 in tissue, organ, and cellular aging. OGG1 promotes cell cycle, and its expression level decreases with aging. Reducing OGG1 can lead to tissue cell aging and cell cycle arrest. The mechanism of OGG1 in anti-aging involves its interaction with p53, thereby through regulating p53-p21 pathway. Here, longevous represents delayed aging, and peach of immortality mountain represents OGG1, the arrows surrounding peach of immortality mountain symbolize the cell cycle,indicating their interaction. Moreover, the cane in the hand of the longevous symbolizes p53.
This cover is designed by Yinxi Zhou and Jianfeng Jin from Hainan Medical University.
Impact Factor3.7
Five-year Impact Factor3.9
{{lang == 'en_US' ? 'CSCD Impact Factor' : 'CSCD影响因子'}}0.4353
CiteScore 20224.4
Editor-in-ChiefDing, Jianping
Ding, Jianping
Ding, Jianping
Cover Story
8-Oxoguanine DNA glycosylase protects cells from senescence via the p53-p21 pathway
Shenglan Gao, Lujun Chen, Ziying Lin, Zhiliang Xu, Yahong Wang, Huayu Ling, Zijun Wu, Yu Yin4, Weimin Yao, Keng Wu, and Gang Liu
p53, the tumor suppressor, plays an important role in senescence via its downstream target p21. The DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) involves in early embryonic development, and in a variety of diseases such as lung fibrosis, diabetes, and neurodegenerative diseases. This article investigates the important protective role of OGG1 in tissue, organ, and cellular aging. OGG1 promotes cell cycle, and its expression level decreases with aging. Reducing OGG1 can lead to tissue cell aging and cell cycle arrest. The mechanism of OGG1 in anti-aging involves its interaction with p53, thereby through regulating p53-p21 pathway. Here, longevous represents delayed aging, and peach of immortality mountain represents OGG1, the arrows surrounding peach of immortality mountain symbolize the cell cycle,indicating their interaction. Moreover, the cane in the hand of the longevous symbolizes p53.
This cover is designed by Yinxi Zhou and Jianfeng Jin from Hainan Medical University.